ATF3 SUSTAINS IL-22-INDUCED STAT3 PHOSPHORYLATION TO MAINTAIN MUCOSAL IMMUNITY THROUGH INHIBITING PHOSPHATASES

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases

In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity.Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel viqua-f4 disease (IBD) and some of them are considered as promising therapeutic targets.However, new perspectives are still neede

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Acute Severe Cushing Syndrome: Not Always Ectopic Acth Syndrome

ABSTRACT: Objective: Cushing syndrome (CS) is a rare disease that results from prolonged supraphysiologic tissue action of glucocorticoids.Cushing disease is the most frequent cause of endogenous CS and is associated with increased morbidity and mortality.Disease onset and severity reflects the magnitude of cortisol excess, and ectopic adrenocortic

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Smart cities & crowdsourcing. A bottom-up approach

Objectives The main aim of our paper is to offer some creative & innovative ways of using crowdsourcing in order to improve the wellbeing of both individuals and local communities by providing alternative solutions to real-life problems inspired mostly from some local best practices examples.Prior work As a trend, there are a lot of national and re

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Effects of Cardiac Rehabilitation Program on Right Ventricular Function after Coronary Artery Bypass Graft Surgery

Background: Cardiac rehabilitation has puffy spa headband been recognized as one of the most effective strategies for managing cardiovascular indices as well as controlling the cardiovascular risk profile, in particular after coronary artery bypass graft surgery (CABG).However, the effect of this program on right ventricular function following CABG

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